There is different type of bone graft:

- Autograft: the surgeon removes bone from another part of your skeleton (often from the iliac crest) and implants it into the defect. The disadvantage of this common procedure is that the surgeon needs to create an additional incision in order to obtain the graft.  This results in two surgery sites, two scars, additional infection risk, and sometimes more pain.

- Allograft & Xenograft: The bone graft comes respectively from a human donor or an animal donor. These kinds of bone graft are regularly used but they pose some risk of infection, immunologic reaction, or viral transmission.

- Synthetic: Among the different kinds of synthetics, Graftys, guided by its collaboration with well known academic laboratories, decided to work with calcium phosphate, which mimics the natural bone mineral composition. According to the last scientifically data,   Graftys synthetic calcium phosphate seems to represent the best option for bone reconstruction because it is safe and efficient; synthetic products pose no risk of viral transmission and require no second surgery site.

Graftys synthetic bone grafts are safe; synthetic products carry no risk of viral transmission or immunologic reaction and it does not require an additional surgical site on another part of your body to remove autologous bone.

Your surgeon will decide if bone graft is required for your procedure. Bone grafts are used principally for reconstitution of bone stock:

- In orthopedics, to fill a bone defect in order to insure long term support for a metal device. New bone gradually replaces the bone graft.

- In trauma, to fill a bone defect created to an injury,

- In dentistry, to fill a bone void and reconstruct your maxillofacial bone to implant a new tooth or simply to stabilize your natural teeth,

Example of injectable bone substitute used in orthopedics surgery:

Graftys is working on osteoporosis since its creation. This disease affects a significant percentage of the population of industrialized nations. Osteoporosis affects 80% of women over the age of  55. Consequences can be dramatic and 24% of osteoporotic hip fracture patients died within one year after their fracture. (NOF, USA). The estimated cost of osteoporosis in 2006 for public health insurance was 53 billions dollars in Europe and 34 billions dollars in the USA. According to the National Osteoporosis Foundation (USA), 25-50% of osteoporotic persons do not take their medications regularly because of undesirable effects of the drugs and because symptoms of this disease are often not apparent to the patient until the occurrence of a fracture.

We are developing a bone graft which is a combination of an anti-osteoporotic drug and a synthetic bone graft substitute to prevent the risk of osteoporotic fracture.  

We are working on smart biomaterials; combinations of different drugs and bone graft substitutes with the aim of building new quality bone while delivering locally the appropriate drug. A local treatment is often more efficient than a systemic one and reduces the quantity of needed drugs and side effects associated to it.  Graftys is working on different kinds of bone graft substitute that will be used in the future:

- Pain relief for traumatic bone defect.

- Reduction of infection risks thanks to an association between a bone graft substitute and an antibiotic.

- Osteoporotic fracture prevention and healing for osteoporotic persons thanks to an association between a bone graft substitute and an antiosteoporotic. The aim is to increase local bone density in osteoporotic patient.