BIOACTYS® GRANULES

About

BIOACTYS® GRANULES are a macroporous Biphasic Calcium Phosphate Biomaterial for bone void filling. It is an osteoconductive biomaterial that is fully integrated within the bone environment. BIOACTYS GRANULES have an advanced porous structure with clinically proven efficacy. BIOACTYS GRANULES facilitate cellular reconstruction which is adapted to the natural kinetics of bone remodeling. Through the use of granules of different diameters, BIOACTYS GRANULES remains the best choice for synthetic bone void filling in dental surgery such as periodontal bone defects and peri-implant bone filling.
BIOACTYS® GRANULES are replaced by new bone and provide stabilization of the operated site.

Composition

BIOACTYS® GRANULES are composed of a 60% Hydroxyapatite and 40% β-Tricalcium Phosphate mix:
• HA : Hydroxyapatite, Ca10 (PO4)6 (OH)2, Bone-bonding material, low dissolution rate
• β-TCP: Beta Tricalcium Phosphate, Ca3 (PO4)2, High dissolution rate

Physicochemical properties

Available Initial Porosity
Global Porosity: 70% distributed as below:
• Micro porosity (pores<10 µm): 45%;
• Meso porosity (10 - 100 µm): 20%;
• Macro porosity (>100 µm): 35%

Mechanism of action

BIOACTYS® GRANULES are a macroporous biomaterial with a composition similar to the crystalline phase of the bone. The porosity structure of BIOACTYS® GRANULES can be fully penetrated by biological fluids and cells. β-TCP is partially dissolved before precipitating as apatite crystals on the HA structure. These apatite crystals, similar to native bone crystals, promote cellular adhesion to start the natural resorption cycle. The low dissolution rate of HA offers a stable scaffold needed for cells to form bone (rapid dissolution can lead to fibrosis and seroma). Bone formation occurs throughout the material and occurs simultaneously with resorption of the implant.

Features