GRAFTYS® BCP

About

GRAFTYS® BCP is a safe and effective synthetic biomaterial. It is a bi-phasic phosphocalcic micro/macro porous ceramic where chemical composition has been balanced to pprovide a balanced resorption/substitution process. The porosity structure has been fine-tuned by using a proprietary transitional porogenic process which improves interconnectivity and optimizes fluid percolation and cell invasion. GRAFTYS® BCP is available in a wide variety of shapes to address many clinical requirements.

Composition

GRAFTYS® BCP is composed of a 60%/40% mix of:
• HA : Hydroxyapatite, Ca10 (PO4)6 (OH)2, Bone-bonding material, low dissolution rate
• β-TCP: Beta Tricalcium Phosphate, Ca3 (PO4)2, high dissolution rate

Physicochemical properties

Available Initial Porosity
Global Porosity: 70% distributed as below:
• Micro porosity (<10 µm): 45%;
• Meso porosity ([10 - 100 µm]): 20%;
• Macro porosity (>100 µm): 35%

Mechanical compressive strength: >10 MPa. This product has to be used in an intrinsic stable site or in association with material which will stabilize the surgical site.

Preparation : Ready to use

GRAFTYS® BCP can be used either with a sterile saline solution (avoid cellular mortality by drying out) or with patient blood or bone marrow or as graft extender (eg. autologous grafting).

Mechanism of action

GRAFTYS® BCP is a macroporous biomaterial with a composition similar to the crystalline phase of the bone. The porosity structure of GRAFTYS® BCP can be fully penetrated by biological fluids and cells. β-TCP is partially dissolved before precipitating as apatite crystals on the HA structure. These apatite crystals, similar to native bone crystals, promote cellular adhesion to start the natural resorption cycle. The low dissolution rate of HA offers a stable scaffold needed for cells to form bone (rapid dissolution can lead to fibrosis and seroma). Bone formation occurs throughout the material and occurs simultaneously with resorption of the implant. 

Features